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Publications

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Nanomedicines Targeting Glioma Stem Cells

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Arjun Sabu, Te-I Liu, Siew Suan Ng, Ruey-An Doong, Yu-Fen Huang*, and Hsin-Cheng Chiu*, 2023, ACS Applied Materials & Interfaces, 15(1), 158-181

IF = 10.383

DOI: https://doi.org/10.1021/acsami.2c03538

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Photothermal/NO combination therapy from plasmonic hybrid nanotherapeutics against breast cancer

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Reesha Kv, Chun-Liang Lo , Hsin-Hung Chen, Ming-Yin Shen, Ying-Chieh Yang, Arjun Sabu,  Yu-Feng Huang, Hsin-Cheng Chiu*, 2022, Journal of Controlled Release, 345, 417 432

IF = 11.467

DOI: https://doi.org/10.1016/j.jconrel.2022.03.030

1-s2.0-S016836592030479X-ga1_lrg.jpg

Tumor microenvironment-responsive and oxygen self-sufficient oil droplet nanoparticles for enhanced photothermal/photodynamic combination therapy against hypoxic tumors.

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Reesha Kv, Te-I Liu, I.-Lin Lu, Chia-Chen Liu, Hsin-Hung Chen, Ting-Yu Lu, Wen-Hsuan Chiang, Hsin-Cheng Chiu*, 2020, Journal of Controlled Release, 328, 87-99.

IF = 11.467

DOI: https://doi.org/10.1016/j.jconrel.2020.08.038

73

New combination treatment from ROS-induced sensitized radiotherapy with nanophototherapeutics to fully eradicate orthotopic breast cancer and inhibit metastasis.

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Te-I Liu, Ting-Yu Lu, Ying-Chieh Yang, Siou-Han Chang, Hsin-Hung Chen, I. Lin Lu, Arjun Sabu, and Hsin-Cheng Chiu*, 2020, Biomaterials, 257, 120229.

IF = 12.479

DOI: https://doi.org/10.1016/j.biomaterials.2020.120229

72

Capturing Amyloid-β Oligomers by Stirring with Microscaled Iron Oxide Stir Bars into Magnetic Plaques to Reduce Cytotoxicity toward Neuronal Cells.

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Yuan-Chung Tsai, Jing-Chian Luo, Te-I Liu, I-Lin Lu, Ming-Yin Shen, Chun-Yu Chuang, Chorng-Shyan Chern, Hsin-Cheng Chiu*, 2020, Nanomaterials, 10, 1284

IF = 5.719

DOI: https://doi.org/10.3390/nano10071284

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Combo-targeted nanoassemblies as a chemotherapy delivery system against peritoneal carcinomatosis colorectal cancer.

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Ming-Yin Shen, Siou-Han Chang, Te-I Liu, Ting-Yu Lu, Arjun Sabu, Hsin-Hung Chen and Hsin-Cheng Chiu*, 2020, Biomaterials Science, 8, 3885-3895

IF = 7.59

DOI: https://doi.org/10.1039/D0BM00583E

Alendronate/folic acid-decorated polymeric nanoparticles for hierarchically targetable chemotherapy against bone metastatic breast cancer.

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Shih-Hong Chen, Te-I Liu, Cheng-Ling Chuang, Hsin-Hung Chen, Wen-Hsuan Chiang, Hsin-Cheng Chiu*, 2020, Journal of Materials Chemistry B, 8, 3789-3800

IF = 7.571

DOI: https://doi.org/10.1039/D0TB00046A

Dual stimuli-guided lipid-based delivery system of cancer combination therapy.

 

Te-I Liu, Ting-Yu Lu, Siou-Han Chang, Ming-Yin Shen, Hsin-Cheng Chiu*, 2020, Journal of Controlled Release, 318, 16-24.

IF = 11.467

DOI: https://doi.org/10.1016/j.jconrel.2019.12.002

IR780-loaded zwitterionic polymeric nanoparticles with acidity-induced agglomeration for enhanced tumor retention.

 

Te-I Liu, Ting-Yu Lu, Siou-Han Chang, Ming-Yin Shen, Hsin-Cheng Chiu*, 2020, European Polymer Journal, 122, 109400.

IF = 5.546

DOI: https://doi.org/10.1016/j.eurpolymj.2019.109400

Indocyanine green/doxorubicin-encapsulated functionalized nanoparticles for effective combination therapy against human MDR breast cancer.

 

Hsin-Hung Chen, I-Lin Lu, Te-I Liu, Yuan-Chung Tsai, Wen-Hsuan Chiang, Sung-Chyr Lin, Hsin-Cheng Chiu*, 2019, Colloids and Surfaces B: Biointerfaces, 177, 294-305

IF = 6.34

DOI: https://doi.org/10.1016/j.colsurfb.2019.02.001

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  1. Yu-Wei Yen, Yi-Lin Lee, Lu-Yi Yu, Cheng-En Li, Pei-Wei Shueng, Hsin-Cheng Chiu, Chun-Liang Lo, Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression, International Journal of Biological Macromolecules, 2023, 250, 126211.

  2. Lu-Yi Yu, Pei-Wei Shueng, Hsin-Cheng Chiu, Yu-Wei Yen, Tzu-Yu Kuo, Chieh-Ru Li, Ming-Wei Liu, Chia-Hsin Ho, Tzu-Hao Ho, Bo-Wei Wang, Cheng-En Li, Ming-Hung Chen, Yao-An Shen, Chun-Liang Lo, Glucose transporter 1-mediated transcytosis of glucosamine-labeled liposomal ceramide targets hypoxia niches and cancer stem cells to enhance therapeutic efficacy, ACS Nano, 2023, 17, 14, 13158–13175. 

  3. Arjun Sabu, Te-I Liu, Siew Suan Ng, Ruey-An Doong, Yu-Fen Huang,* and Hsin-Cheng Chiu*, Nanomedicines Targeting Glioma Stem Cells, ACS Appl. Mater. Interfaces, 2023, 15, 1, 158–181. 

  4. I.-Lin Lu, Ting-Wei Yu, Te-I Liu, Hsin-Hung Chen, Ying-Chieh Yang, Chun-Liang Lo, Chi-Ya Wang, and Hsin-Cheng Chiu*, Microfluidized Dextran Microgels Loaded with Cisplatin/SPION Lipid Nanotherapeutics for Local Colon Cancer Treatment via Oral Administration, Advanced Healthcare Materials, 2022, 11, 2201140.

  5. Yu-Han Wen, Po-I Hsieh, Hsin-Cheng Chiu, Chil-Wei Chiang, Chun-Liang Lo, Yi-Ting Chiang, Precise delivery of doxorubicin and imiquimod through pH-responsive tumor microenvironment-active targeting micelles for chemo and immunotherapy, Materials Today Bio, 2022, 17, 100482. 

  6. Bo-Wei Chen, Shadie Hatamie, Hsin-Cheng Chiu, Zung-Hang Wei, Shang-Hsiu Hu* and Da-Jeng Yao*, Shape-mediated magnetocrystalline anisotropy and relaxation controls by cobalt ferrite core–shell heterostructures for magnetothermal penetration delivery, Advanced Materials Interfaces, 2022, 2200022. 

  7. Pei-Wei Shueng, Lu-Yi Yu, Hsiao-Hsin Hou, Hsin-Cheng Chiu and Chun-Liang Lo, Charge conversion polymer–liposome complexes to overcome the limitations of cationic liposomes in mitochondrial-targeting drug delivery, International Journal of Molecular Sciences, 2022, 23, 3080-3098. 

  8. Reesha Kakkadavath Vayalakkara, Chun-Liang Lo, Hsin-Hung Chen, Ming-Yin Shen, Ying-Chieh Yang, Arjun Sabu, Yu-Feng Huang*, Hsin-Cheng Chiu*, Photothermal/NO combination therapy from plasmonic hybrid nanotherapeutics against breast cancer, Journal of Controlled Release, 2022, 345, 417–43. 

  9. Keiko Tezuka, Masakazu Umezawa*, Te-I Liu, Koki Nomura, Kyohei Okubo, Hsin-Cheng Chiu, Masao Kamimura, and Kohei Soga*, Upconversion luminescent nanostructure with ultrasmall ceramic nanoparticles coupled with rose bengal for NIR-induced photodynamic therapy, ACS Applied Bio Materials, 2021, 4, 4462-4469. 

  10. Arjun Sabu, Jui-Yen Lin, Ruey-An Doong, Yu-Fen Huang* and Hsin-Cheng Chiu*, Prospects of an engineered tumor-targeted nanotheranostic platform based on NIR-responsive upconversion nanoparticles, Materials Advances, 2021, 2, 7101–7117. 

  11. Pei-Wei Shueng, Lu-Yi Yu, Hsin-Cheng Chiu, Hui-Ching Chang, Yen-Ling Chiu, Tzu-Yu Kuo, Yu-Wei Yen, Chun-Liang Lo*, Early phago-/endosomal escape of platinum drugs via ROS-responsive micelles for dual cancer chemo/immunotherapy, Biomaterials, 2021, 276, 121012. 

  12. Shiou-Fen Hung, Yu-Han Wen, Lu-Yi Yu, Hsin-Cheng Chiu, Yi-Ting Chiang* and Chun-Liang Lo*, Development of a rapid-onset, acid-labile linkage polyplex-mixed micellar system for anticancer therapy, Polymers, 2021, 13, 1823. 

  13. Te-I Liu, Ting-Yu Lu, Ying-Chieh Yang, Siou-Han Chang, Hsin-Hung Chen, I.-Lin Lu, Arjun Sabu, Hsin-Cheng Chiu*, New combination treatment from ROS-induced sensitized radiotherapy with nanophototherapeutics to fully eradicate orthotopic breast cancer and inhibit metastasis. Biomaterials, 2020, 257, 120229. 

  14. Reesha Kv, Te-I Liu, I.-Lin Lu, Chia-Chen Liu, Hsin-Hung Chen, Ting-Yu Lu, Wen-Hsuan Chiang, Hsin-Cheng Chiu*, Tumor microenvironment-responsive and oxygen self-sufficient oil droplet nanoparticles for enhanced photothermal/photodynamic combination therapy against hypoxic tumors. Journal of Controlled Release, 2020, 328, 87-99. 

  15. Ming-Yin Shen, Siou-Han Chang, Te-I Liu, Ting-Yu Lu, Arjun Sabu, Hsin-Hung Chen, Hsin-Cheng Chiu*, Combo-targeted nanoassemblies as a chemotherapy delivery system against peritoneal carcinomatosis colorectal cancer, Biomaterials Science, 2020, 8, 3885-3895. 

  16. Te-I Liu, Ting-Yu Lu, Siou-Han Chang, Ming-Yin Shen, Hsin-Cheng Chiu*, Dual stimuli-guided lipid-based delivery system of cancer combination therapy, Journal of Controlled Release, 2020, 318, 16-24. (SCI)

  17. Shih-Hong Chen, Te-I Liu, Cheng-Ling Chuang, Hsin-Hung Chen, Wen-Hsuan Chiang, Hsin-Cheng Chiu*, Alendronate/folic acid-decorated polymeric nanoparticles for hierarchically targetable chemotherapy against bone metastatic breast cancer, Journal of Materials Chemistry B, 2020, 8, 3789-3800. (SCI)

  18. Te-I Liu, Yuan-Chung Tsai, Te-Ming Wang, Siou-Han Chang, Ying-Chieh Yang, Hsin-Hung Chen, Hsin-Cheng Chiu*, Development of a nano-immunomodulator encapsulating R837 and caffeine for combined radio-/immunotherapy against orthotopic breast cancer. Progress in Natural Science: Materials International, 2020, 30, 697-706. 

  19. Yuan-Chung Tsai, Jing-Chian Luo, Te-I Liu, I.-Lin Lu, Ming-Yin Shen, Chun-Yu Chuang, Chorng-Shyan Chern, Hsin-Cheng Chiu*, Capturing amyloid-β oligomers by stirring with microscaled iron oxide stir bars into magnetic plaques to reduce cytotoxicity toward neuronal cells. Nanomaterials, 2020, 10, 1284. 

  20. I-Lin Lu, Te-I Liu, Hsiao-Chieh Lin, Siou-Han Chang, Chun-Liang Lo, Wen-Hsuan Chiang, Hsin-Cheng Chiu*, IR780-loaded zwitterionic polymeric nanoparticles with acidity-induced agglomeration for enhanced tumor retention, European Polymer Journal, 2020, 122, 109400. (SCI)

  21. Ming-Yin Shen, Te-I Liu, Ting-Wei Yu, Reesha Kv, Wen-Hsuan Chiang, Yuan-Chung Tsai, Hsin-Hung Chen, Sung-Chyr Lin, Hsin-Cheng Chiu*, Hierarchically targetable polysaccharide-coated solid lipid nanoparticles as an oral chemo/thermotherapy delivery system for local treatment of colon cancer, Biomaterials, 2019, 197, 86-100. (SCI)

  22. Hsin-Hung Chen, I.-Lin Lu, Te-I Liu, Yuan-Chung Tsai, Wen-Hsuan Chiang, Sung-Chyr Lin, Hsin-Cheng Chiu*, Indocyanine green/doxorubicin-encapsulated functionalized nanoparticles for effective combination therapy against human MDR breast cancer, Colloids and Surfaces B: Biointerfaces, 2019, 177, 294-305. (SCI)

  23. Kai-Ting Hou, Te-I Liu, Hsin-Cheng Chiu, Wen-Hsuan Chiang*, DOX/ICG-carrying γ-PGA-g-PLGA-based polymeric nanoassemblies for acid-triggered rapid DOX release combined with NIR-activated photothermal effect, European Polymer Journal, 2019, 110, 283-292. (SCI)

  24. Te-I Liu, Ying-Chieh Yang, Wen-Hsuan Chiang, Chun-Kai Hung, Yuan-Chung Tsai, Chi-Shiun Chiang, Chun-Liang Lo, Hsin-Cheng Chiu*, Radiotherapy-controllable chemotherapy from reactive oxygen species-responsive polymeric nanoparticles for effective local dual modality treatment of malignant tumors, Biomacromolecules, 2018, 19, 3825-3839.

  25. Ankan Dutta Chowdhury, Akhilesh Babu Ganganboina, Yuan-Chung Tsai, Hsin-Cheng Chiu*, Ruey-An Doong*, Multifunctional GQDs- concanavalin A@Fe3O4 nanocomposites for cancer cells detection and targeted drug delivery, Analytica Chimica Acta, 2018, 1027, 109-120.

  26. Te-I Liu, Ying-Chieh Yang, Wen-Hsuan Chiang, Chun-Kai Hung, Yuan-Chung Tsai, Chi-Shiun Chiang, Chun-Liang Lo, Hsin-Cheng Chiu*, Radiotherapy-controllable chemotherapy from reactive oxygen species-responsive polymeric nanoparticles for effective local dual modality treatment of malignant tumors, Biomacromolecules, 2018, 19, 3825-3839. 

  27. Yuan-Chung Tsai, Priya Vijayaraghavan, Wen-Hsuan Chiang, Hsin-Hung Chen, Te-I Liu, Ming-Yin Shen, Ayumu Omoto, Masao Kamimura, Kohei Soga*, and Hsin-Cheng Chiu*, Targeted delivery of functionalized upconversion nanoparticles for externally triggered photothermal/photodynamic therapies of brain glioblastoma, Theranostics, 2018, 8, 1435-1448. 

  28. Masao Kamimura,* Ayumu Omoto, Hsin-Cheng Chiu, and Kohei Soga*, Enhanced red upconversion emission of NaYF4:Yb3+, Er3+, Mn2+ nanoparticles for near-infrared induced photodynamic therapy and fluorescence imaging, Chemistry Letters, 2017, 46, 1076-1078.

  29. Yu-Lin Su, Ting-Wei Yu, Wen-Hsuan Chiang, Hsin-Cheng Chiu, Chun-Hsiang Chang, Chi-Shiun Chiang, Shang-Hsiu Hu, Hierarchically targeted and penetrated delivery of drugs to tumors by size-changeable graphene quantum dot nanoaircrafts for photolytic therapy, Advanced Functional Materials, 2017, 27, 1700056. (SCI)

  30. Wen-Chia Huang, I-Lin Lu, Wen-Hsuan Chiang, Yi-Wen Lin, Yuan-Chung Tsai, Hsin-Hung Chen, Chien-Wen Chang, Chi-Shiun Chiang, Hsin-Cheng Chiu*, Tumortropic adipose-derived stem cells carrying smart nanotherapeutics for targeted delivery and dual-modality therapy of orthotopic glioblastoma, Journal of Controlled Release, 2017, 254, 119-130. (SCI)

  31. Wen-Chia Huang, Shih-Hong Chen, Wen-Hsuan Chiang, Chu-Wei Huang, Chun-Liang Lo, Chorng-Shyan Chern, Hsin-Cheng Chiu*, Tumor microenvironment-responsive nanoparticle delivery of chemotherapy for enhanced selective cellular uptake and transportation within tumor, Biomacromolecules, 2016, 12, 3883-3892. (SCI)

  32. Ting-Wei Yu, I.-Lin Lu, Wen-Chia Huang, Shang-Hsiu Hu, Chia-Chian Hung, Wen-Hsuan Chiang and Hsin-Cheng Chiu*, Acidity-triggered surface charge neutralization and aggregation of functionalized nanoparticles for promoted tumor uptake, RSC Advances, 2016, 6, 36293-36295. (SCI)

  33. Chia-Chian Hung, Wen-Chia Huang, Yi-Wen Lin, Ting-Wei Yu, Hsin-Hung Chen, Sung-Chyr Lin, Wen-Hsuan Chiang*, and Hsin-Cheng Chiu*, Active tumor permeation and uptake of surface charge-switchable theranostic nanoparticles for imaging-guided photothermal/chemo combinatorial therapy, Theranostics, 2016, 6, 302–317. (SCI)

  34. Wen-Chia Huang, Ming-Yin Shen, Hsin-Hung Chen, Sung-Chyr Lin, Wen-Hsuan Chiang, Pei-Hsuan Wu, Chien-Wen Chang, Chi-Shiun Chiang and Hsin-Cheng Chiu*, Monocytic delivery of therapeutic oxygen bubbles for dual-modality treatment of tumor hypoxia, Journal of Controlled Release, 2015, 220, 738-750. (SCI)

  35. Wen-Chia Huang, Wen-Hsuan Chiang, Ya-Hui Cheng, Wan-Chi Lin, Ching-Fang Yu, Chia-Yi Yen, Chih-Kuang Yeh, Chorng-Shyan Chern, Chi-Shiun Chiang* and Hsin-Cheng Chiu*, Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia, Biomaterials, 2015, 71, 71-83. (SCI)

  36. Hsin-Hung Chen, Wen-Chia Huang, Wen-Hsuan Chiang, Te-I Liu, Ming-Yin Shen, Yuan-Hung Hsu, Sung-Chyr Lin* and Hsin-Cheng Chiu*, pH-Responsive therapeutic solid lipid nanoparticles for reducing p-glycoprotein-mediated drug efflux of MDR cancer cells, International Journal of Nanomedicine, 2015, 10, 5035-5048. (SCI)

  37. Wei-Hong Jian, Ting-Wei Yu, Chien-Ju Chen, Wen-Chia Huang, Hsin-Cheng Chiu*, and Wen-Hsuan Chiang*, Indocyanine green-encapsulated hybrid polymeric nanomicelles for photothermal cancer therapy, Langmuir, 2015, 31, 6202-10.(SCI)

  38. Wen-Chia Huang, Yung-Chu Chen, Yuan-Hung Hsu, Wen-Yuan Hsieh* and Hsin-Cheng Chiu*, Development of a diagnostic polymersome system for potential imaging delivery, Colloids and Surfaces B: Biointerfaces, 2015, 128, 67–76. (SCI)

  39. Yi-Fong Huang, Wen-Hsuan Chiang, Wen-Chia Huang, Hsin-Hong Chen, Ming-Yin Shen, Sung-Chyr Lin, Chorng-Shyan Chern, Hsin-Cheng Chiu*, pH-Responsive hierarchical transformation of charged lipid assemblies within polyelectrolyte gel layers with applications for controlled drug release and MR imaging contrast, Journal of Materials Chemistry B, 2014, 2, 4988-4992. (SCI)

  40. Wen-Hsuan Chiang, Wen-Chia Huang, Ming-Yin Shen, Che-Hsu Wang, Yi-Fong Huang, Sung-Chyr Lin, Chorng-Shyan Chern, Hsin-Cheng Chiu*, Dual-layered nanogel-coated hollow lipid/polypeptide conjugate assemblies for potential pH-triggered intracellular drug release, PLoS ONE, 2014, 9, e92268. (SCI)

  41. Wen-Hsuan Chiang, Viet Thang Ho, Hsin-Hung Chen, Wen-Chia Huang, Yi-Fong Huang, Sung-Chyr Lin, Chorng-Shyan Chern, and Hsin-Cheng Chiu*, Superparamagnetic hollow hybrid nanogels as a potential guidable vehicle system of stimuli-mediated MR imaging and multiple cancer therapeutics, Langmuir, 2013, 29, 6434−6443. (SCI)

  42. Wen-Hsuan Chiang, Wen-Chia Huang, Chien-Wen Chang, Ming-Yin Shen, Zong-Fu Shih, Yi-Fong Huang, Sung-Chyr Lin, and Hsin-Cheng Chiu*, Functionalized polymersomes with outlayered polyelectrolyte gels for potential tumor-targeted delivery of multimodal therapies and MR imaging, Journal of Controlled Release, 2013, 168 280–288. (SCI)

  43. Wen-Hsuan Chiang, Viet Thang Ho, Wen-Chia Huang, Yi-Fong Huang, Chorng-Shyan Chern, and Hsin-Cheng Chiu*, Dual stimuli-responsive polymeric hollow nanogels designed as carrier for intracellular triggered drug release, Langmuir, 2012, 28, 15056-15064. (SCI)

  44. Wen-Hsuan Chiang, Yu-Jen Lan, Yun-Chiao Huang, Yu-Wen Chen, Yi-Fong Huang, Sung-Chyr Lin, Chorng-Shyan Chern, and Hsin-Cheng Chiu*, Multi-scaled polymersomes from self-assembly of octadecanol-modified dextrans, Polymer, 2012, 53, 2233-2244. (SCI)

  45. Wen-Chia Huang, Wen-Husan Chiang, Su-Jen Lin, Yu-Jen Lan, Hsin-Lung Chen, Chrong-Shyan Chern, and Hsin-Cheng Chiu*, Lipid-containing polymer vesicles with pH/Ca2+ ions-manipulated size-selective permeability, Advanced Functional Materials, 2012, 22, 2267-2275. (SCI)

  46. Yi-Fong Huang, Wen-Husan Chiang, Pei-Ling Tsai, Chrong-Shyan Chern, and Hsin-Cheng Chiu*, Novel hybrid vesicles co-assembled from cationic lipid and PAAc-g-mPEG with pH-triggered transmembrane channels for controlled drug release, Chemical Communications, 2011, 47, 10978-10980. (SCI)

  47. Wen-Husan Chiang, Yuan-Hung Hsu, Chrong-Shyan Chern, and Hsin-Cheng Chiu*, Two-stage thermally induced stable colloidal assemblies from PAAc/PNIPAAm/mPEG graft copolymer in water, Polymer, 2011, 52, 2422-2429. (SCI)

  48. Wen-Chia Huang, Wen-Husan Chiang, Yi-Fong Huang, Sung-Chyr Lin, Zong-Fu Shih, Chrong-Shyan Chern, and Hsin-Cheng Chiu*, Nano-scaled pH-responsive polymeric vesicles for intracellular release of doxorubicin, Journal of Drug Targeting, 2011, 19, 944-53. (SCI)

  49. Yi-Fong Huang, Wen-Husan Chiang, Pei-Ling Tsai, Chrong-Shyan Chern, Hsin-Cheng Chiu*, Novel hybrid vesicles co-assembled from cationic lipid and PAAc-g-mPEG with pH-Triggered transmembrane channels for controlled drug release, Chemical Communications, 2011, 47, 10978-80.

  50. Wen-Husan Chiang, Yuan-Hung Hsu, Yi-Wei Chen, Chrong-Shyan Chern, Hsin-Cheng Chiu*, Thermoresponsive interpolymeric complex assemblies from co-association of linear PAAc-homopolymers with PNIPAAm segments containing PAAc-based graft copolymer, Macromolecular Chemistry and Physics, 2011, 212, 1869 (SCI)

  51. Wen-Husan Chiang, Yuan-Hung Hsu, Chrong-Shyan Chern, Hsin-Cheng Chiu*, Two-stage thermally induced stable colloidal assemblies from PAAc/PNIPAAm/mPEG graft copolymer in water, Polymer, 2011, 52, 2422 (SCI)

  52. Wen-Hsuan Chiang, Yuan-Hung Hsu, Fa-Fen Tang, Chorng-Shyan Chern, Hsin-Cheng Chiu*, Temperature/pH-induced morphological regulations of shell cross-linked graft copolymer assemblies, Polymer, 2010, 51, 6248-6257. (SCI)

  53. Wen-Husan Chiang, Yuan-Hung Hsu, Tzu-Wei Lou, Chorng-Shyan Chern, and Hsin-Cheng Chiu*, Effects of mPEG grafts on morphology and cross-linking of thermally induced micellar assemblies from PAAc-based graft copolymers in aqueous phase, Macromolecules, 2009, 42, 3611-3619. (SCI)

  54. Wen-Husan Chiang, Yuan-Hung Hsu, Chorng-Shyan Chern, and Hsin-Cheng Chiu*, Thermally induced polymeric assemblies from PAAc-based copolymer containing both PNIPAAm and mPEG grafts in water, J. Phys. Chem. B, 2009, 113, 4187-4196. (SCI)

  55. Ray-Yi Lin, Bang-Shuo Chen, Guan-Liang Chen, Jeng-Yue Wu, Hsin-Cheng Chiu, Shing-Yi Suen*, Preparation of porous PMMA/Na+–montmorillonite cation-exchange membranes for cationic dye adsorption, J. Membrane Sci., 2009, 326, 117-129. (SCI)

  56. Hsin-Cheng Chiu*, Yue-Wen Lin, Yi-Fong Huang, Chih-Kai Chuang, and Chorng-Shyan Chern, Polymer vesicles containing small vesicles within interior aqueous compartments and pH-responsive transmembrane channels, Angew. Chem. Int. Ed., 2008, 47, 1875-1878. (selected as a VIP and cover picture of the Journal) (SCI)

  57. Guo-Jing Chen, Ming-Cheng Yen, Jen-Ming Wang, Jiang-Jen Lin, and Hsin-Cheng Chiu*, Layered inorganic/enzyme nanohybrids with selectivity and structural stability upon interacting with biomolecules, Bioconjugate Chemistry, 2008, 19,138-144. (SCI)

  58. Chao-Shuan Chang, Ho-Sheng Ni, Shing-Yi Suen*, Wen-Chi Tseng, Hsin-Cheng Chiu, and C. Perry Chou, Preparation of inorganic-organic anion exchange membranes and their application in plasmid DNA and RNA separation, J. Membrane Sci., 2008, 311, 336-348.(SCI)

  59. Yuan-Hung Hsu, Wen-Hsuan Chiang, Mu-Chin Chen, Chorng-Shyan Chern, and Hsin-Cheng Chiu*, Effects of SDS on the thermo- and pH-sensitive structural changes of the PAAc-based copolymer containing both PNIPAAm and PEG grafts in water, Langmuir, 2006, 22, 6764-6770. (SCI)

  60. Chorng-Shyan Chern*, Hsin-Cheng Chiu, and Yu-Shiue Yang, Interactions between nonionic Triton X surfactants and cholesterol-containing phosphatidylcholine liposomes, J. Colloid and Interface Science, 2006, 302, 335-340. (SCI)

  61. Chorng-Shyan Chern*, Wei-Yih Chen, Hsin-Cheng Chiu, Fu-Hsiung Chang, Ming-Hung Hsieh, and Jia-Ren Tu, Interactions between amphiphilic graft copolymer-intercalated liposomes, Colloids and Surfaces A, 2006, 277, 44-51. (SCI)

  62. Yuan-Hung Hsu, Wen-Hsuan Chiang, Chien-Hsian Chen, Chorng-Shyan Chern, and Hsin-Cheng Chiu*, Thermally responsive interactions between the PEG and PNIPAAm grafts attached to the PAAc backbone and the corresponding structural changes of polymeric micelles in water, Macromolecules, 2005, 38, 9757-9765. (SCI)

  63. Hsin-Cheng Chiu*, Tin Hsiue and Wei-Young Chen, FTIR-ATR measurements of the ionization extent of acrylic acid within copolymerized methacrylated dextran/acrylic acid networks and its relation with pH/salt concentration-induced equilibrium swelling, Polymer, 2004, 45, 1627-1636. (SCI) 

  64. Chorng-Shyan Chern*, Hsin-Cheng Chiu and Yi-Ching Chuang, Synthesis and characterization of amphiphilic copolymers with PEG and cholesterol side chains, Polymer International, 2004, 53, 420-429. (SCI) 

  65. Yi-Jun Chen, Liang-Wei Huang, Hsin-Cheng Chiu and Sung-Chyr Lin*, Temperature-responsive polymer-assisted protein refolding, Enzyme & Microbial Technology, 2003, 32, 120-130. (SCI) 

  66. Hsin-Cheng Chiu*, Yi-Fong Lin and Shen-Hsiue Hung, Equilibrium swelling of copolymerized acrylic acid-methacrylated dextran networks: Effects of pH and neutral salt, Macromolecules, 2002, 35, 5235-5242. (SCI) 

  67. Hsin-Cheng Chiu*, Yuan-Hung Hsu and Pei-Jung Lin, Synthesis of pH-sensitive inulin hydrogels and characterization of their swelling properties, Journal of Biomedical Materials Research, 2002, 61, 146-152. (SCI) 

  68. Hsin-Cheng Chiu*, Yi-Fong Lin and Yuan-Hung Hsu, Effects of acrylic acid on preparation and swelling properties of pH-sensitive hydrogels, Biomaterials, 2002, 23, 1103-1112. (SCI) 

  69. Hsin-Cheng Chiu*, An-Tie Wu and Yi-Fong Lin, Synthesis and characterization of acrylic acid-containing dextran hydrogels, Polymer, 2001, 42, 1471-1479. (SCI)

  70. Jan-An Guu, Tzuoh-Miin Juang, Ging-Ho Hsiue* and Hsin-Cheng Chiu, Synthesis of dextran-(5-FU)-galactosamine conjugate through a tripeptide spacer group and its in vitro properties, J. Chin. Inst. Chem. Engrs., 2000, 31, 351-359. (SCI)

  71. Fu-Ya Wang and Hsin-Cheng Chiu*, Preparation of ethylcellulose-menadiol microcapsules and investigation of their properties in the presence of a protective colloid, Journal of Engineering, National Chung Hsing University, 2000, 11 (2), 23-34.

  72. Hsin-Cheng Chiu* and Chau-Hui Wang, Synthesis of temperature/pH-sensitive hydrogels containing disulfide linkages as crosslinks and their characterization, Polymer Journal, 2000, 32, 574-582. (SCI) 

  73. Shing-Yi Suen*, Shu-Ying Lin and Hsin-Cheng Chiu, The Effect of spacer arms on cibacron blue 3GA immobilization and lysozyme adsorption using regenerated cellulose membrane discs, Industrial & Engineering Chemistry Research, 2000, 39, 478-487. (SCI)

  74. Shing-Yi Suen*, Hsin-Cheng Chiu and Yi-Da Tsai, Polysaccharide-modified polysulfone hollow fibers as solid supports for affinity adsorption, Separation Science and Technology, 2000, 35, 1343-1362. (SCI)

  75. Sung-Chyr Lin*, Kai-Li Lin, Hsin-Cheng Chiu and Suryani Lin, Enhanced protein renaturation by temperature-responsive polymers, Biotech. Bioengr., 2000, 67, 505-512. (SCI)

  76. Hsin-Cheng Chiu*, Chun-Liang Lo and Fu-Ya Wang, Effects of protective colloids upon properties of ethylcellulose microcapsules prepared from various non-solvent addition methods, J. Chin. Inst. Chem. Engrs., 1999, 30, 491-499. (SCI)

  77. Hsin-Cheng Chiu, Chun-Hsia Hu and Chorng-Shyan Chern*, Preparation and characterization of amphiphilic poly (ethylene glycol) graft copolymers, Polymer Journal, 1999, 31, 535-541. (SCI) 

  78. Hsin-Cheng Chiu*, Ging-Ho Hsiue, Yang-Ping Lee and Liang-Wei Huang, Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system, J. Biomaterials Sci. Polym. Ed., 1999, 10, 591-608. (SCI)

  79. Shing-Yi Suen*, Hsin-Cheng Chiu and Yi-Da Tsai, Surface modification of polysulfone microfiltration hollow fiber and its affinity adsorption, Journal of Engineering, National Chung Hsing University, 1998, 9 (2), 75-82. 

  80. Hsin-Cheng Chiu, Chorng-Shyan Chern*, Cheng-Kang Lee and Hui-Fang Chang, Synthesis and characterization of amphiphilic poly(ethylene glycol) graft copolymers and their potential applications as drug carriers, Polymer, 1998, 39, 1609-1616. (SCI)

  81. Hsin-Cheng Chiu, Pavla Kopeckova, Sharad S, Deshmane and Jindrich Kopecek*, Lysosomal degradability of poly(alpha-amino acids), Journal of Biomedical Materials Research, 1997, 34, 381-392. (SCI)

  82. Hsin-Cheng Chiu, Cestmir Konak, Pavla Kopeckova and Jindrich Kopecek, Enzymatic degradation of poly(ethylene glycol) modified dextrans, Journal of Bioactive and Compatible Polymers, 1994, 9, 338-410. (SCI)

  83. Hsin-Cheng Chiu, Samuel,Zalipsky, Pavla Kopeckova and Jindrich Kopecek**, enzymatic cactivity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates, Bioconjugate Chemistry, 1993, 4, 290-295. (SCI))

  84. Hsin-Cheng Chiu, Chun-Hsia Hu and Chorng-Shyan Chern*, Preparation and characterization of amphiphilic poly (ethylene glycol) graft copolymers, Polymer Journal, 1999, 31, 535-541. (SCI) 

  85. Hsin-Cheng Chiu*, Ging-Ho Hsiue, Yang-Ping Lee and Liang-Wei Huang, Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system, J. Biomaterials Sci. Polym. Ed., 1999, 10, 591-608. (SCI)

  86. Shing-Yi Suen*, Hsin-Cheng Chiu and Yi-Da Tsai, Surface modification of polysulfone microfiltration hollow fiber and its affinity adsorption, Journal of Engineering, National Chung Hsing University, 1998, 9 (2), 75-82. 

  87. Hsin-Cheng Chiu, Chorng-Shyan Chern*, Cheng-Kang Lee and Hui-Fang Chang, Synthesis and characterization of amphiphilic poly(ethylene glycol) graft copolymers and their potential applications as drug carriers, Polymer, 1998, 39, 1609-1616. (SCI)

  88. Hsin-Cheng Chiu, Pavla Kopeckova, Sharad S, Deshmane and Jindrich Kopecek*, Lysosomal degradability of poly(alpha-amino acids), Journal of Biomedical Materials Research, 1997, 34, 381-392. (SCI)

  89. Hsin-Cheng Chiu, Cestmir Konak, Pavla Kopeckova and Jindrich Kopecek, Enzymatic degradation of poly(ethylene glycol) modified dextrans, Journal of Bioactive and Compatible Polymers, 1994, 9, 338-410. (SCI)

  90. Hsin-Cheng Chiu, Samuel,Zalipsky, Pavla Kopeckova and Jindrich Kopecek**, enzymatic cactivity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates, Bioconjugate Chemistry, 1993, 4, 290-295. (SCI))

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